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Other drugs, such as anticonvulsants and antipsychotics are used as augmentation therapy to increase the overall response to therapy when symptoms persist after receiving treatment with first-line anti-anxiety drugs.

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WARNING: Cyclosporine is a drug that reduces the body's ability to fight illness/disease (an immunosuppressant), leaving patients vulnerable to infection or other problems (including cancers such as lymphoma). Using other drugs that treat organ transplant rejection along with this drug may increase these tendencies. Cyclosporine can also cause high blood pressure and kidney problems. The risk of both problems increases with higher doses and longer treatment with this drug. Psoriasis patients who have had certain previous treatments (e.g., coal tar, methotrexate, PUVA, UVB, or other radiation therapy) are at increased risk to develop skin cancer. Therefore, cyclosporine must be given only under close medical supervision. Because different brands deliver different amounts of medication, do not switch brands of cyclosporine without your doctor's permission and directions. Laboratory tests (e.g., kidney function tests, blood tests) may be performed to monitor your progress.Lactic acidosis is a rare, but serious complication that can occur due to metformin accumulation. The risk increases with conditions such as sepsis, dehydration, excess alcohol intake, hepatic insufficiency, renal impairment, and acute congestive heart failure.The antipsychotic ziprasidone (Geodon) prolongs the QT interval, which could lead to fatal heart arrhythmias in some patients. Ziprasidone should not be given to those with a history of QT prolongation or to those who may be taking other drugs that prolong the QT interval.

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Benzodiazepines frequently cause drowsiness; therefore, care should be taken when operating machinery or motor vehicles.

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